Tobacco obviously! but cigarettes and cigarette smoke contain more than 4,000 chemicals, of which 400 are known to be toxic and over 60 that are cancer causing or carcinogenic.
Some of these chemicals are added to improve the bitter taste of tobacco or keep the cigarette burning. Others are added to help nicotine vapour be absorbed by your lungs to speed up the 'hit'.
Most of the harmful substances in tobacco smoke are found at low levels in a single cigarette. But over months and years, many of them can build up to high levels in our bodies.
This is why a smoker’s risk of cancer and other diseases increases the more cigarettes they smoke a day, and the more years they spend smoking.
Compared to non-smokers, the breath and blood of smokers can have:
Nicotine is found naturally in the tobacco plant. It is a neurotoxin (a poison that kills nerve cells) and the plant uses it to stop animals from eating it.
Tobacco plants absorb various chemicals from the soil and fertilisers. These become stored in the leaves and are released when the leaves are burned. These chemicals include metals like cadmium, arsenic and chromium.
Tobacco plants have large leaves with sticky hairs called trichomes. These hairs can capture chemicals such as radioactive polonium-210 from the atmosphere, building up higher concentrations than other plants.
The leaves can also absorb and concentrate chemicals used in fertilisers and pesticides.
Some dangerous chemicals are formed when tobacco leaves are processed and cigarettes are manufactured.
For example, when tobacco is cured to remove moisture from the leaves, bacteria produce nitrites that react with chemicals in the leaves. This produces most of the nitrosamines in the final product. Many of these chemicals are unique to tobacco and not found in other plants.
Most of the dangerous chemicals in tobacco smoke are formed through the many chemical reactions that occur as the cigarette burns.
Burning organic material such as tobacco leaves produces polycyclic aromatic hydrocarbons. And sugars that are added to cigarettes produce formaldehyde when burned.
Hundreds of chemicals are added to cigarettes in order to make them taste nicer and easier to smoke. This include the irritating gas, ammonia, which can increase the addictive power of nicotine.